ENHANCING THE CIRCULATING HALF-LIFE OF ANTIBODY-BASED FUSION PROTEIN

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods of enhancing the circulating half-life of antibody-based fusion proteins.

SOLUTION: The methods and compositions rely on altering the amino acid sequence of the junction region between the antibody moiety and the fused protein moiety in an antibody-based fusion protein. An antibody-based fusion protein with an altered amino acid sequence in the junction region has a greater circulating half-life when administered to a mammal. The methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal.

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