发明名称 |
OLIGOSACCHARIDES AND OLIGOSACCHARIDE-PROTEIN CONJUGATES DERIVED FROM CLOSTRIDIUM DIFFICILE POLYSACCHARIDE PS-II, METHODS OF SYNTHESIS AND USES THEREOF, IN PARTICULAR AS A VACCINE |
摘要 |
<p>The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the Clostridium difficile glycopolymer PS-II and a protein carrier. More specifically, the oligosaccharide is the hexasaccharide having the following formula (I) wherein R is a linker or spacer group. In a specific embodiment of the invention, R is (CH2)nNH2, with n being an integer from 2 to 50. The present invention also provides the use of said oligosaccharide and said oligosaccharide-protein conjugate for the treatment or prevention of a disease caused by the pathogen Clostridium difficile. In still further aspects, the present invention also provides a favourable method for preparing said oligosaccharide and said oligosaccharide-protein conjugate.</p> |
申请公布号 |
WO2012119769(A1) |
申请公布日期 |
2012.09.13 |
申请号 |
WO2012EP01014 |
申请日期 |
2012.03.07 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR;SEEBERGER, PETER H.;OBERLI, MATTHIAS;HECHT, MARIE-LYN |
发明人 |
SEEBERGER, PETER H.;OBERLI, MATTHIAS;HECHT, MARIE-LYN |
分类号 |
A61K39/08;A61K39/40;A61K39/44;A61P1/12;A61P31/04;C08B37/00;C08L5/00;C12P19/04 |
主分类号 |
A61K39/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|