发明名称 |
Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
摘要 |
<p>The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non- modified anti-CD3 antibodies.</p> |
申请公布号 |
EP2497496(A2) |
申请公布日期 |
2012.09.12 |
申请号 |
EP20120166907 |
申请日期 |
2006.07.11 |
申请人 |
MACROGENICS, INC. |
发明人 |
KOENIG, SCOTT;JOHNSON, LESLIE S.;BONVINI, EZIO;WILDER, RONALD |
分类号 |
A61K39/395;A61P37/02;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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