摘要 |
An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like. |
申请人 |
SEKIGUCHI KAZUO;SUZUKI TAKASHI;OHBUCHI YUTAKA;OKUNO MITSUHIRO;OHI NAOTO;OHNISHI KENJI;MOTOYAMA MASAAKI;YOSHIDA KENJI;KODAMA TAKESHI;SUGIYAMA KAZUHISA;AKAMATSU SEIJI;KIYONO KUNIHIKO;YANAGIHARA YASUO;WATANABE TAKASHI;HAYASHI KAZUHIKO;TANAKA HIDEO;SUMIDA TAKUMI;OTSUKA PHARMACEUTICAL CO., LTD. |
发明人 |
SEKIGUCHI KAZUO;SUZUKI TAKASHI;OHBUCHI YUTAKA;OKUNO MITSUHIRO;OHI NAOTO;OHNISHI KENJI;MOTOYAMA MASAAKI;YOSHIDA KENJI;KODAMA TAKESHI;SUGIYAMA KAZUHISA;AKAMATSU SEIJI;KIYONO KUNIHIKO;YANAGIHARA YASUO;WATANABE TAKASHI;HAYASHI KAZUHIKO;TANAKA HIDEO;SUMIDA TAKUMI |