发明名称 |
Stable bortezomib formulations |
摘要 |
Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base.
|
申请公布号 |
US8263578(B2) |
申请公布日期 |
2012.09.11 |
申请号 |
US201213431313 |
申请日期 |
2012.03.27 |
申请人 |
SOPPIMATH KUMARESH;PEJAVER SATISH;PATEL KANAIYALAL R.;DASARADHI LAKKARAJU;SODUM RAMA;DESU HARI;PURI NAVNEET;INNOPHARMA, INC. |
发明人 |
SOPPIMATH KUMARESH;PEJAVER SATISH;PATEL KANAIYALAL R.;DASARADHI LAKKARAJU;SODUM RAMA;DESU HARI;PURI NAVNEET |
分类号 |
A01N55/08;A61K31/4965;A61K31/69;C07D241/00;C07D241/02;C07F5/02;C07F5/04;C07F7/02 |
主分类号 |
A01N55/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|