发明名称 |
Method of gene transfer via vascular system or ureter |
摘要 |
The present invention provides a method for gene transfer through the vascular system or a ureter. In a preferable embodiment of this invention, an aqueous solution containing an expression vector comprising a desired gene is injected through the vascular system or a ureter of a desired organ to introduce the gene into the injected area. Specifically, the method of the present invention is effective for ex vivo gene therapy wherein the hepatocyte growth factor (HGF) gene is introduced by electroporation into a kidney to be transplanted. According to the present invention, the HGF functions continuously on the kidney to be transplanted, and the HGF within the treated area does not affect other organs of the body. Thus, the method of the present invention is a safe and effective treatment for maintaining the survival of transplanted kidneys. |
申请公布号 |
US8263756(B2) |
申请公布日期 |
2012.09.11 |
申请号 |
US20040474142 |
申请日期 |
2004.04.23 |
申请人 |
TAKAHARA SHIRO;IMAI ENYU;ISAKA YOSHITAKA;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
TAKAHARA SHIRO;IMAI ENYU;ISAKA YOSHITAKA |
分类号 |
C07H21/02;A61K38/18;A61K48/00;A61P13/12;A61P37/06;C07H21/04;C07K14/475 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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