发明名称 AZA-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
摘要 The present invention provides compounds are disclosed herein having the formula: Wherein n is 1 or 2; m is 0 or 1; R1 is aryl, heteroaryl or alkyl; R2 is C1-6 hydrocarbyl, alkylacyl or hydroxyalkyl; R3 is aryl, heteroaryl, or alkyl; R4 is H, OH, —O—(C1-6 alkyl), —NH—(C1-6 alkyl), or oxide; R5 is H, halogen, C1-6 alkyl, O—(C1-6 alkyl), aryl, heteroaryl, —C(═O)(C1-6 alkyl), substituted or un-substituted oxazolin-2-yl; X=O, NH, —C(═O)— or —N═CH—; and Each L is independently alkylene and carbonyl.
申请公布号 US8263767(B2) 申请公布日期 2012.09.11
申请号 US201113195130 申请日期 2011.08.01
申请人 YUAN HAIQING;BEARD RICHARD L.;ALLERGAN, INC. 发明人 YUAN HAIQING;BEARD RICHARD L.
分类号 C07D487/04 主分类号 C07D487/04
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