发明名称 |
Method for deprotecting aryl or alkyl sulfonamides of primary or secondary amines |
摘要 |
The invention relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by contacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material in the presence of a solid proton source under conditions sufficient to form the corresponding amine. The invention also relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by a) reacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal-silica gel material, and b) subsequently reacting the reaction product from step a) with an electrophile or a proton source. Preferred Stage 0 or Stage I alkali metal-silica gel materials include Na, K2Na, and Na2K. |
申请公布号 |
US8263808(B2) |
申请公布日期 |
2012.09.11 |
申请号 |
US20070300409 |
申请日期 |
2007.02.13 |
申请人 |
LEFENFELD MICHAEL;DYE JAMES L.;NANDI PARTHA;JACKSON JAMES;SIGNA CHEMISTRY, INC. |
发明人 |
LEFENFELD MICHAEL;DYE JAMES L.;NANDI PARTHA;JACKSON JAMES |
分类号 |
C07C209/00 |
主分类号 |
C07C209/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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