| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: disclosed is a method of producing crystals of a basic amino acid hydrochloride from a basic amino acid sulphate fermentation broth or an fermentation reaction solution. The fermentation reaction is catalysed by viable microbial cells which produce a basic amino acid selected from a group consisting of arginine, lysine, ornithine, and histidine. The broth or solution is characterised by equivalent ratio of the sulphate ion/basic amino acid from 50 to 150%. A metal chloride is added to the basic amino acid sulphate fermentation broth or fermentation reaction solution, said metal being selected from: calcium, potassium, magnesium and barium, in equivalent ratio from 80 to 120% with respect to the sulphate ion. The pH is kept in the range from 3 to 8.5 and temperature from 20 to 90C. Metal sulphate crystals are then removed. The obtained broth or fermentation solution is then cooled, while keeping concentration of the metal sulphate below its saturated concentration value. Crystals of the basic amino acid hydrochloride are then separated and accumulated. ^ EFFECT: method enables to obtain crystals of a basic amino acid hydrochloride with high purity and high output. ^ 2 cl, 3 tbl, 3 ex |
