| 摘要 |
<p>The present invention relates to the disorganization and/or deregulation of the circadian system and/or body clock, and associated diseases, conditions and symptoms associated therewith. The invention also relates to desynchronosis and jet lag, and to the prevention or treatment of jet lag and/or the diseases, conditions and/or symptoms associated therewith. The present invention further relates to modulators of glucocorticoid level and/or activity and to compositions for and methods of preventing or treating symptoms and/or diseases associated with jet lag. More particularly, the present invention relates to a modulator of glucocorticoid biosynthesis and/or a modulator of glucocorticoid degradation and/or a modulator of glucocorticoid receptor activation for use in preventing or treating symptoms and/or diseases associated with jet lag or as a lead compound for developing a drug for preventing or treating symptoms and/or diseases associated with jet lag, wherein administration of the modulator(s) to a subject results in a directional change of the time point of maximum amounts of glucocorticoids in the subject as compared to the time point of maximum amounts of glucocorticoids in a subject not treated with the modulator(s).</p> |
