ENHANCED TUMOR THERAPY BY TUMOR STEM CELL TARGETED ONCOLYTIC VIRUSES
摘要
The invention relates to recombinant oncolytic viruses that target tumor stem cells and various uses of these recombinant viruses. In particular, an oncolytic virus comprising a recombinant binding domain specific for a tumor stem cell marker is disclosed. Furthermore, the use of such oncolytic viruses for the treatment of cancer is disclosed.
申请公布号
WO2012117116(A2)
申请公布日期
2012.09.07
申请号
WO2012EP53728
申请日期
2012.03.05
申请人
BUNDESREPUBLIK DEUTSCHLAND, LETZTVERTRETEN DURCH DEN PRAESIDENTEN DES PAUL-EHRLICH-INSTITUTS, PROF.DR. KLAUS CICHUTEK;BUCHHOLZ, CHRISTIAN;BACH, PATRICIA;ABEL, TOBIAS