| 摘要 |
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (-)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess. |
| 申请人 |
CODEXIS, INC.;ANG, EE LUI;CLAY, MICHAEL, D.;BEHROUZIAN, BEHNAZ;EBERHARD, ELLEN;COLLIER, STEVEN, J.;FU FAN, JASYLN;SMITH, DEREK;SONG, SHIWEI;ALVIZO, OSCAR;WIDEGREN, MAGNUS;ZHU, JUN;XU, JUNYE;WILSON, ROBERT |
发明人 |
ANG, EE LUI;CLAY, MICHAEL, D.;BEHROUZIAN, BEHNAZ;EBERHARD, ELLEN;COLLIER, STEVEN, J.;FU FAN, JASYLN;SMITH, DEREK;SONG, SHIWEI;ALVIZO, OSCAR;WIDEGREN, MAGNUS;ZHU, JUN;XU, JUNYE;WILSON, ROBERT |
