A method for predicting a subject's response to a TUSC2 therapy is provided. In particular, a subject's response is predicted based on the proportion of cancers cells that are apoptotic. Also provided is a method of treating a subject previously predicted to have a favorable response with a TUSC2 therapy. Methods for treating cancer by adminsirtation of a TUSC2 therapeutic in conjunction with an EGFR inhibitor and/or a protein kinase inhibitor are also disclosed. Kits and reagents for use in TUSC2 therapy are provided.
申请公布号
WO2012119095(A1)
申请公布日期
2012.09.07
申请号
WO2012US27529
申请日期
2012.03.02
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;ROTH, JACK;STEWART, DAVID;LU, CHARLES;WISTUBA, IGNATIO;YAN, SHAOYU;NUNEZ, MARIA, I.
发明人
ROTH, JACK;STEWART, DAVID;LU, CHARLES;WISTUBA, IGNATIO;YAN, SHAOYU;NUNEZ, MARIA, I.