发明名称 |
Methods and Compositions for Improved Deliver, Expression or Activity of RNA Interference Agents |
摘要 |
The present disclosure provides methods and compositions for enhanced delivery of siRNA or miRNA, into the interior of multilayered tissues, and into the cytoplasm or nucleus of cells of a tissue. Such methods and compositions yield tumor-selective and intracellular delivery of RNAi agents and allow for RNAi-mediated activity such as knock-down of the target genes and associated products. The current disclosure further provides methods and compositions for improving the intracellular bioavailability of nucleotide agents.
|
申请公布号 |
US2012225115(A1) |
申请公布日期 |
2012.09.06 |
申请号 |
US201213444798 |
申请日期 |
2012.04.11 |
申请人 |
AU JESSIE L.-S.;WIENTJES M. GUILLAUME;LU ZE;WANG JIE |
发明人 |
AU JESSIE L.-S.;WIENTJES M. GUILLAUME;LU ZE;WANG JIE |
分类号 |
A61K9/127;A61K31/704;A61K31/7105;A61K31/713;A61P35/00;C12N5/09 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|