| 发明名称 |
Anti-alpha2 integrin antibodies and their uses |
| 摘要 |
<p>The invention relates to anti-α2 integrin antibodies and their uses. Humunized antibodies are disclosed that bind to the I domain ofα2 integrin and inhibit the interaction ofα2β1 integrin with collagen. Also disclosed are therapeutic uses of anti-α2 integrin antibodies in treatingα2β1-mediated disorders, including anti-α2 integrin antibodie s that bind toα2 integrin without activating platelets.</p> |
| 申请公布号 |
AU2006315037(B2) |
申请公布日期 |
2012.09.06 |
| 申请号 |
AU20060315037 |
申请日期 |
2006.11.17 |
| 申请人 |
GLENMARK PHARMACEUTICALS S.A. |
发明人 |
LAZARIDES, ELIAS;BERNARD, MARK;WOODS, CATHERINE |
| 分类号 |
C12N15/13;A61K39/395;A61P19/00;A61P35/00;A61P37/02;C07K14/705;C07K14/78;C07K16/28;C12N5/10;C12N15/63;C12P21/08;G01N33/53;G01N33/543;G01N33/566 |
主分类号 |
C12N15/13 |
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