| 发明名称 |
ICOS critically regulates the expansion and function of inflammatory human Th17 cells |
| 摘要 |
<p>The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents,</p> |
| 申请公布号 |
AU2011212794(A1) |
申请公布日期 |
2012.09.06 |
| 申请号 |
AU20110212794 |
申请日期 |
2011.02.04 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
RILEY, JAMES L.;PAULOS, CHRYSTAL;JUNE, CARL H.;LEVINE, BRUCE |
| 分类号 |
A61K39/39;A61K35/12;A61K39/395 |
主分类号 |
A61K39/39 |
| 代理机构 |
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代理人 |
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