发明名称 |
NOVEL 2-PYRIDONE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME |
摘要 |
Disclosed is a novel 2-pyridone derivative represented by general formula (1), which has both angiotensin II receptor antagonist activity and PPAR-γ activating activity and is useful as a prophylactic and/or therapeutic agent for cardiovascular diseases and metabolic diseases. Also disclosed is a pharmaceutical composition which contains the novel 2-pyridone derivative. In general formula (1), R1 represents a C1-6 alkyl group or a C1-6 alkoxy group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; R3 represents a C1-6 alkyl group, a C6-10 aryl-C1-6 alkyl group, a C1-6 alkoxy-C1-6 alkyl group or a group represented by formula (2) (wherein A represents a nitrogen atom or CH, and R5 represents a hydrogen atom or a C1-6 alkoxy group); and R4 represents a group represented by formula (3) or (4). |
申请公布号 |
US2012225896(A1) |
申请公布日期 |
2012.09.06 |
申请号 |
US201013509130 |
申请日期 |
2010.12.22 |
申请人 |
MIURA TORU;TAGASHIRA JUNYA;SEKIMOTO RYOHEI;ISHIDA RIE;AOKI HITOMI;OHGIYA TADAAKI;KOWA COMPANY, LTD. |
发明人 |
MIURA TORU;TAGASHIRA JUNYA;SEKIMOTO RYOHEI;ISHIDA RIE;AOKI HITOMI;OHGIYA TADAAKI |
分类号 |
A61K31/506;A61K31/4439;A61K31/444;A61P3/00;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P13/12;C07D401/10;C07D401/14;C07D413/10;C07D413/14 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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