ARRAY-BASED METHOD FOR DETECTION OF COPY NUMBER VARIATIONS IN THE HLA LOCUS FOR THE GENETIC DETERMINATION OF SUSCEPTIBILITY OF DEVELOPMENT OF VENOUS MALFORMATIONS IN THE EXTRACRANIAL SEGMENTS OF THE CEREBROSPINAL VEINS AND KIT THEREOF

摘要

Method for in vitro diagnosis of susceptiblility of developing venous malformations i the extracranial segment of the cerebrospinal veins in a patient comprising the detection of copy number variations (CNVs) in chromosome 6p21 in a sample of genomic DNA of the patient, wherein the venous malformations are associated with the development of multiple sclerosis.