发明名称 |
5-AMINOLEVULINIC ACID-CONJUGATED HYALURONIC ACID NANOPARTICLES FOR PHOTODYNAMIC THERAPY |
摘要 |
PURPOSE: A photosensitizer used for photodynamic therapy(PDT) is provided to minimize side effects and to enable quick treatment for patients. CONSTITUTION: An aminolebulinic acid-conjugated hyaluronic acid nanoparticle photodynamic therapy(PDT) is a photosensitizer of hyaluronic acid-histidine-aminolebulinic acid(HAhs-ALA) conjugate. The size of the photosensitizer is 50-300 nm. A method for preparing the photosensitizer comprises: a step of conjugating hydrizid to a carboxyl group of hyaluronic acid by covalent bond; a step of conjugating histidine by covalent bond to form a hyaluronic acid-histidine(HAhs) conjugate; and a step of conjugating hyaluronic acid to an amine group of the conjugate to prepare a hyaluronic acid-histidine-aminolebulinic acid conjugate.
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申请公布号 |
KR20120098191(A) |
申请公布日期 |
2012.09.05 |
申请号 |
KR20110017978 |
申请日期 |
2011.02.28 |
申请人 |
PUSAN NATIONAL UNIVERSITY HOSPITAL;PUSAN NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION |
发明人 |
KANG, DAE HWAN;JEONG, YOUNG IL;CHUNG, CHUNG WOOK;CHOI, KYUNG HA |
分类号 |
A61K9/16;A61K31/197;A61K47/36;A61K47/48 |
主分类号 |
A61K9/16 |
代理机构 |
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