HUMANIZED RECOMBINANT URICASE AND MUTANTS THEREOF

摘要

The present invention provides a humanized recombinant uricase and mutants thereof, wherein the humanized recombinant uricase is a chimeric protein which comprises amino acids of non-human mammal uricase and amino acids of human uricase. The humanized recombinant uricase and mutants thereof have reduced immunogenicity in human, and can be used for the treatment of hyperuricemia and gout.