The present application relates to methods for treating cancer in a subject by modulating the phosphorylation of the Serine 42 of Twist1 by administering to said subject a therapeutically effective amount of a modulator of said phosphorylation of the Serine 42 of Twist1. Antibodies, uses methods and biomarkers based on the phosphorylation of the Serine 42 of Twist1 are also provided.
申请公布号
EP2493492(A1)
申请公布日期
2012.09.05
申请号
EP20100771123
申请日期
2010.10.28
申请人
NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
发明人
HEMMINGS, BRIAN ARTHUR;GRESKO, EKATARINA;VYCHALKOVSKIY, ANTON;XUE, GONGDA