PYRAZOLE DERIVATIVES, PREPARATION THEREOF AND COMPOSITION COMPRISING THE SAME FOR PREVENTION AND TREATMENT OF OSTEOPOROSIS

摘要

PURPOSE: A pyrazole derivative compound and a composition containing the same are provided to suppress reactive oxygen generation and to prevent or treat osteoporosis without side effect. CONSTITUTION: A pyrazole derivative compound is denoted by chemical formula 1. Pharmaceutically acceptable salt of the compound of chemical formula 1 is hydrochloride. A method for preparing the compound or pharmaceutically acceptable salt thereof of chemical formula 1 comprises: a step of dropping a compound of chemical formula 2 and a compound of chemical formula 3 to polar organic solvent at -4 to 10 Deg. C.; and a step of heating the poly organic solvent at 90-130 Deg. C. The polar organic solvent is C1-C4 alcohol, acetic acid, or a mixture thereof. A composition for preventing or treating osteroporosis contains the compound of chemical formula 1.