GALACTOSYLATED POLYETHYLENE GLYCOL-CHITOSAN-GRAFT-SPERMINE COPOLYMER AS A HEPATOCYTE TARGETING GENE CARRIER AND GENE THERAPY USING THE SAME

摘要

PURPOSE: A lactosylated polyethylene glycol-chitosan-g-spermine copolymer is provided to have excellent transduction efficiency of hepatocyte targeting, while having low cytotoxicity. CONSTITUTION: A galactosylated polyethylene glycol-chitosan-graft-spermine copolymer is in chemical formula 1. A manufacturing method of the copolymer comprises a step of synthesizing polyethylene glycol by reacting galactose-containing glycoprotein, and a bifunctional polyethylene glycol; a step of manufacturing a chitosan-graft-spermine copolymer by reacting chitosan and spermine; and a step of reacting the galactosylated polyethylene glycol and the chitosan-graft-spermine copolymer.