发明名称 |
Process for the preparation of temozolomide and analogs |
摘要 |
A process for the preparation of compounds of formula IA, where R═CH3 (i.e. temozolomide): comprising diazotizing a compound of the formula IIA: where in R is as defined above in the presence of at least one metal halide, an acid and a source of nitrous acid, followed by conversion of acidic solution containing temozolomide. The conversion can be carried out by a liquid-liquid extraction technique in a water immiscible solvent. The temozolomide may be further purified in an acetone-water mixture. |
申请公布号 |
US8258294(B2) |
申请公布日期 |
2012.09.04 |
申请号 |
US20070442516 |
申请日期 |
2007.09.28 |
申请人 |
PATHI SRINIVAS LAXMINARAYAN;RAO DHARMARAJ RAMACHANDRA;KANKAN RAJENDRA NARAYANRAO;CIPLA LIMITED |
发明人 |
PATHI SRINIVAS LAXMINARAYAN;RAO DHARMARAJ RAMACHANDRA;KANKAN RAJENDRA NARAYANRAO |
分类号 |
C07D487/04;A61K31/4188;A61P35/00;C07D233/90 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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