| 发明名称 |
TARGETED RETROGRADE GENE DELIVERY TO MOTOR NEURONS |
| 摘要 |
Methods are disclosed for delivering a heterologous gene to a cell body of a neuron by contacting either the synaptic portion of a neuron, for example or a muscle tissue innervated by the neuron, with a viral vector comprising a heterologous gene, wherein the viral vector enters said neuron and is retrogradely moved to the cell body. Additionally, methods for expressing secreted proteins from a nerve cell body as well as methods for treating neurodegenerative disorders are described.
|
| 申请公布号 |
CA2471812(C) |
申请公布日期 |
2012.09.04 |
| 申请号 |
CA20022471812 |
申请日期 |
2002.12.20 |
| 申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
KASPAR, BRIAN K.;GAGE, FRED H.;PETERSON, DANIEL;ROTHSTEIN, JEFFREY D. |
| 分类号 |
C12N15/09;C12N15/86;A61K31/7088;A61K31/711;A61K35/76;A61K38/00;A61K38/27;A61K48/00;A61P3/04;A61P9/10;A61P11/06;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P27/02;A61P27/06;C07K14/47;C12N5/06;C12N5/0793;C12N15/864 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
