发明名称 ANTINEOPLASTIC COMBINATIONS CONTAINING HKI-272 AND VINORELBINE
摘要 Use of a vinorelbine compound (4-(acetyloxy)-6,7-didehydro-15-((2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino(4,3-b)indol-8-yl)-3-hydroxy-16-methoxy-1-methyl- methyl ester, (2beta, 3beta, 4beta, 5alpha, 12R, 19alpha)-aspidospermidine-3-carboxylic acid) and a HKI-272 ((E)-N-{ 4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyI} -4-(dimethylamino)-2-butenamide) compound in the manufacture of a medicament for treating a neoplasm in a subject, wherein said neoplasm is selected from the group consisting of a lung cancer, breast cancer, myeloma, prostate cancer, head and neck cancer, transitional cell carcinoma, small cell neuroendocrine carcinoma of the uterine cervix, and large cell neuroendocrine carcinoma of the uterine cervix.
申请公布号 NZ590009(A) 申请公布日期 2012.08.31
申请号 NZ20090590009 申请日期 2009.06.17
申请人 WYETH LLC 发明人 ZACHARCHUK, CHARLES
分类号 A61K31/436;A61K31/4745;A61P35/00 主分类号 A61K31/436
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