ANTI CXCR4 ANTIBODIES AND THEIR USE FOR THE TREATMENT OF CANCER

摘要

Provided is the process for the selection of an anti-CXCR4 antibody~ or one of its functional fragments or derivatives~ capable to inhibit activation of CXCR4~ characterized in that it comprises the following steps: i) screening the generated antibodies and selecting antibodies capable to bind to CXCR4 and also to modulate CXCR4 activation; ii) testing the selected antibodies of step i) and selecting antibodies capable to induce CXCR4 homodimers conformational change and then iii) testing the selected antibodies of step ii) and selecting antibodies capable to induce CXCR4/CXCR2 heterodimers conformational change. Further provided are such antibodies and nucleotide sequences coding for the antibodies. The antibodies can be used to treat various cancers.