| 摘要 |
<p>The disclosure relates to an oral pharmaceutical liquid formulation comprising deferiprone and a taste masking composition, said taste masking composition comprising an effective amount of a sweetener (such as sucralose) per litre of liquid formulation, an effective amount of a thickening and suspension aid, (for example hydroxyethylcellulose), per litre of liquid formulation, an effective amount of a humectant (such as glycerin) per litre of liquid formulation, and an effective amount of at least one flavoring agent, wherein a final form of said oral liquid pharmaceutical formulation has a substantially non-bitter and palatable taste. A palatable liquid pharmaceutical formulation specifically comprises: about 50-200 grams of deferiprone per litre of the formulation, about 15 grams of sucralose per litre of the formulation, about 500 grams of glycerin per litre of the formulation, about 1 gram of hydroxyethylcellulose per litre of the formulation, about 59 grams of concentrated hydrochloric acid per litre of the formulation, about 0040 grams of FD&C Yellow No.6 per litre of the formulation, about 2 grams of artificial cherry flavour per litre of the formulation, about 0.10 grams of peppermint oil per litre of the formulation and a sufficient amount of purified water to yield 1 litre of the formulation.</p> |
