SIGNATURES AND PCDETERMINANTS ASSOCIATED WITH PROSTATE CANCER AND METHODS OF USE THEREOF

摘要

A model for prostate cancer that comprises a homozygous disruption in both the Pten gene and Smad4 gene. The model can be used to identified PCDETERMINANTS that are differentially expressed in metastatic cancer, including SPP1 and Cyclin D. The genes Pten, Smad4, Spp1 and cyclin D can be used in methods for diagnosing and monitoring the cancer as well as for identifying compounds that can treat the cancer.