| 发明名称 |
METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY |
| 摘要 |
A method of assessing effectiveness of a cancer treatment in a subject administered a PD-L1 antagonist, said method comprising: measuring PD-I expression on T cells in a biological sample from the subject ex vivo, wherein a decrease in PD-I expression on the T cells indicates that the PD-L1 antagonist is efficacious for treating cancer. |
| 申请公布号 |
NZ593388(A) |
申请公布日期 |
2012.08.31 |
| 申请号 |
NZ20060593388 |
申请日期 |
2006.06.08 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE;EMORY UNIVERSITY;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
FREEMAN, GORDON;SHARPE, ARLENE;DORFMAN, DAVID M |
| 分类号 |
C07K16/28;A61K39/395;G01N33/53 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
