SINGLE-CHAIN FC (SCFC) REGIONS, BINDING POLYPEPTIDES COMPRISING SAME, AND METHODS RELATED THERETO

摘要

Disclosed is isolated binding polypeptide comprising (i) a first binding site, and (ii) an Fc region consisting of a single polypeptide chain encoded in a single contiguous genetic sequence wherein: a. said Fc region is a heteromeric Fc region and comprises at least two Fc moieties; b. said Fc region is fused via a polypeptide linker sequence interposed between said at least two Fc moieties; c. said Fc region imparts at least one effector function to said binding polypeptide; and d. said at least two Fc moieties are folded intramolecularly within said Fc region to form said Fc region.