发明名称 CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
摘要 Disclosed is a compound comprising a 1,2,4 triazine fused to an imidazole or pyrrole ring which is bound to a tetrahydrofuran as depicted in formula (I). The substituents are as disclosed in the description. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) in the manufacture for the treatment of a viral infection caused by a virus selected from the group consisting of dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis virus, St. Louis encephalitis virus, Omsk haemorrhagic fever virus, bovine viral diarrhoea virus, Zika virus and Hepatitis C virus.
申请公布号 NZ588670(A) 申请公布日期 2012.08.31
申请号 NZ20090588670 申请日期 2009.04.22
申请人 GILEAD SCIENCES, INC. 发明人 CHO, AESOP;KIM, CHOUNG, U
分类号 C07D487/04;A61K31/395;A61K31/41;A61K31/4188;A61K31/7052;A61P31/12;C07H19/23 主分类号 C07D487/04
代理机构 代理人
主权项
地址