5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives as inhibitors of Bruton's Tyrosine Kinase (Btk)

摘要

Discloses herein are 5-phenyl-1H-pyridin-2-one and 6-phenyl-2H-pyridazin-3-one derivatives according to generic formulae (III) & (IV), wherein variables R, X, Y1, Y2, Y2', Y3, Y4, n and m are as defined in the specification. These compounds inhibit Bruton's Tyrosine Kinase (Btk) and are useful for the treatment of diseases caused by aberrant B-cell activation. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of formulae (III) & (IV) and at least one carrier, diluent or excipient.