Process for the production of brevikollin-base from Carex brevicollis D.C.

摘要

The invention relates to pharmaceutical industry, in particular to the production of brevikollin-base from Carex brevicollis D.C.The process, according to the invention, comprises drying of the plant material from Carex brevicollis D.C. plants to a humidity of at most 5…7%; its subsequent milling in a hammer mill with a holes sizes of 5x25 mm; treatment of the milled plant material with 1% sulfuric acid solution at the temperature of 80…85°C and the pressure of 16·103...20·103 Pa; extraction in the steady-state regime in an extraction system, formed of at least three capacities in the shape of a funnel connected in series and placed vertically, with 1% sulfuric acid solution at the temperature of 80…85°C during 48 hours; combination of extracts; neutralization and alkalization of the acid extract up to pH 8…9; extraction with organic solvents with intensive stirring for 3…5 min; concentration of the extract up to dry residue; treatment of the dry residue with acetone in the ratio of 1:3 respectively; boiling of suspension with reverse agitation for 10…15 min; cooling to -5…0°C; filtration; washing with cold acetone and drying.