摘要 |
<p>Disclosed is a process for the preparation of 9-dichloromethylene-1,2,3,4-tetrahydro-1,4-methano-naphthalen-5-ylamine of formula I which process comprises a) reacting cyclopentadiene with CXCl3, wherein X is chloro or bromo, in the presence of a radical initiator to a compound of formula II wherein X is chloro or bromo, or aa) reacting cyclopentadiene with CXCl3, wherein X is chloro, in the presence of a metal catalyst to a compound of formula II wherein X is chloro, b) reacting the compound of formula II with a base in the presence of an appropriate solvent to the compound of formula III, c) and converting the compound of formula III in the presence of 1,2-dehydro-6-nitrobenzene to the compound of formula IV and d) hydrogenating the compound of formula IV with a hydrogen source in the presence of a metal catalyst.</p> |
申请人 |
SYNGENTA PARTICIPATIONS AG |
发明人 |
GRIBKOV, DENIS;ANTELMANN, BJORN;GIORDANO, FANNY;WALTER, HARALD;DE MESMAEKER, ALAIN |