| 摘要 |
a) Disclosed herein is a unit dosage form comprising a thin water-soulble film matrix, wherein a) said film matrix comprises at least one water-soluble matrix polymer; b) said film matrix comprises particles where said particles comprises at least one progestin and at least one protective agent, and where said particles have a d90 particle size of ?280µm; c) said film matrix has a thickness of ?300µm; wherein said progestin is selected from the group consisting of levo-norgestrel, norgestrel, norethindrone (norethisterone), dienogest, norethindrone (norethisterone) acetate, ethynodiol diacetate, dydrogesterone, medroxyprogesterone acetate, norethynodrel, allylestrenol, Iynestrenol, quingestanol acetate, medrogestone, norgestrienone, dimethisterone, ethisterone, chlormadinone acetate, megestrol, promegestone, desogestrel, 3-ketodesogestrel, norgestimate, gestodene, tibolone, cyproterone acetate, dienogest and drospirenone, wherein said water-soluble matrix polymer is selected from the group consisting of a cellulosic material, a gum, a protein, a starch, a synthetic polymer, a glucan, and mixtures thereof, and wherein said protective agent is a wax.
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