| 摘要 |
Disclosed is a method for determining a susceptibility to breast cancer in a human individual, comprising determining whether at least one allele of at least one polymorphic marker is present in a nucleic acid sample obtained from the individual, wherein the at least one polymorphic marker is selected from rs13387042, and markers in linkage disequilibrium therewith, wherein linkage disequilibrium is characterized by values of r2 of at least 0.2, and wherein the presence of the at least one allele is indicative of a susceptibility to breast cancer for the individual. Further disclosed is a computer program for determining a genetic indicator for breast cancer in a human individual, wherein the computer program is adapted to be executed on a processor to analyse marker allele and/or haplotype information for at least one human individual with respect to at least one polymorphic marker selected from the markers set forth in rs13387042 and markers in linkage disequilibrium therewith, wherein linkage disequilibrium is characterized by values of r2 of at least 0.2, and generate an output based on the marker or haplotype information, wherein the output comprises an individual risk measure of the at least one marker allele or haplotype as a genetic indicator of breast cancer for the human individual.
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