PHARMACEUTICAL BIOADHESIVE DISK-TYPE PREPARATIONS BASED ON CHLORHEXIDINE METAL COMPLEXES AND PROCESS FOR PREPARING THE SAME

摘要

The invention relates to a pharmaceutical preparation of the bioadhesive disk type, having antimicrobial, antifungal, anti-inflammatory and wound healing effects and to a process for preparing the same. According to the invention, the preparation comprises 0.01...0.1% metal complexes of cyclohexidine with Cu(II), Zn(II), Ag(I), a solution (1:3) of propyl p-hydroxybenzoate : methyl p-hydroxybenzoate, gelatin, sorbitol, glycerol and water, presented as smooth translucent yellowish disks having a surface pH in the range of 4.5...6.25. The process claimed by the invention consists in hot dissolving the weighed starting materials in water, pouring the mixture into moulds, gellifying the same at the ambient temperature, followed by the control and conditioning of the final product.