GLARGINE PROINSULIN COMPOSITIONS AND METHODS OF PRODUCING GLARGINE INSULIN ANALOGS THEREFROM

摘要

GGlargine proinsulin constructs that have a modified C-peptide amino acid and/or nucleic acid sequence for producing glargine insulin analogs are provided. Highly efficient processes for preparing the glargine insulin analogs and improved preparations containing the glargine insulin analogs prepared according to the methods described herein are also provided.