| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a useful method for producing fluoroamines. <P>SOLUTION: Fluoroamines can be produced by: protecting an amino group of an amino alcohol with a nitrobenzenesulfonyl group, thereby converting into a protected amino alcohol (amino group protection step); causing the protected amino alcohols to react with sulfuryl fluoride (SO<SB POS="POST">2</SB>F<SB POS="POST">2</SB>) in the presence of an organic base, thereby converting into a protected fluoroamine (dehydroxyfluorination step); and eliminating the protective group of the amino group of the protected fluoroamines (deprotection step). Since a nitrobenzenesulfonyl group highly satisfies the conditions required for the protective group of an amino group, an aimed fluoroamine can be obtained with high purity and high yield. <P>COPYRIGHT: (C)2012,JPO&INPIT |
