发明名称 |
IMPFSTOFFZUSAMMENSETZUNG, DIE MINDESTENS ZWEI IMMUNOGENE ENTHÄLT, EINES MIT ADJUVANS IMMUNOGEN, EINES OHNE ADJUVANT IMMUNOGEN |
摘要 |
A vaccine composition comprising two valences is provided: (i) a first valence which is adjuvant-enhanced with aluminum hydroxide and (ii) a second valence which contains a polysaccharide of bacterial capsule comprising one or more o-acetyl groups and which is not adsorbed with aluminum oxide due to the presence of a protecting compound which may be a phosphate, a citrate or a carbonate and which prevents the adsorption. The first valence can be any vaccine valence. In one particular embodiment, the vaccine composition contains (i) Hepatitis A valence, adsorbed on aluminum hydroxide and (ii) the typhoid fever valence formed by the polysaccharide Vi of the Salmonella typhi capsule. |
申请公布号 |
DE60219177(T3) |
申请公布日期 |
2012.08.30 |
申请号 |
DE2002619177T |
申请日期 |
2002.07.31 |
申请人 |
SANOFI PASTEUR |
发明人 |
FRANCON, ALAIN |
分类号 |
A61K39/295;A61K39/39;A61K47/02;A61P1/00;A61P31/00;A61P31/04;A61P31/14 |
主分类号 |
A61K39/295 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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