| 发明名称 |
PROCESS FOR TRIPHOSPHATE OLIGONUCLEOTIDE SYNTHESIS |
| 摘要 |
The present invention describes simple, efficient, and enzyme-free method of making oligonucleotides with 5′-triphosphate. This invention presents novel process for synthesizing triphosphate oligonucleotides using a diaryl phosphonate as reagent. The process of the present invention is amenable to large-scale, economic 5′-triphosphate oligonucleotide synthesis. |
| 申请公布号 |
US2012220761(A1) |
申请公布日期 |
2012.08.30 |
| 申请号 |
US200913393851 |
申请日期 |
2009.12.22 |
| 申请人 |
ZLATEV IVAN;MORVAN FRANCOIS;VASSEUR JEAN-JACQUES;DEBART FRANCOISE;MANOHARAN MUTHIAH;ALNYLAM PHARMACEUTICALS, INC. |
发明人 |
ZLATEV IVAN;MORVAN FRANCOIS;VASSEUR JEAN-JACQUES;DEBART FRANCOISE;MANOHARAN MUTHIAH |
| 分类号 |
C07H1/04 |
主分类号 |
C07H1/04 |
| 代理机构 |
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