PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT OR METASTASIS INHIBITION CONTAINING EXPRESSION OR ACTIVATION INHIBITORS OF MAP7D2 PROTEIN, NOVEL CANCER THERAPEUTIC TARGET

摘要

The present invention relates to the pharmaceutical composition for cancer treatment or metastasis inhibition containing expression or activation inhibitors of MAP7D2 protein as an active ingredient. More specifically a novel anti-cancer therapeutic target has been discovered using data-mining techniques by building a large-scale gene expression database of human cancer tissues, and, based on the gene expression profiles of cancer cell lines, appropriate cancer cell lines were selected and experimentally verified through the inhibition of candidate target genes. Through these, MAP7D2 has been verified as a novel potential anti-cancer target which is over-expressed in a variety of cancer tissues or cells, such as cancer tissues or cells of the kidney, lung, large-intestine, ovary, stomach and liver, and inhibition of which impedes the growth, movement, infiltration and metastasis of cancer cells, thereby leading to cell destruction. As such, expression levels of MAP7D2 can be useful as a diagnostic marker for cancer and an MAP7D2 protein expression or activation inhibitor can be used as an active ingredient in a pharmaceutical composition for cancer treatment or metastasis inhibition.