发明名称 HIV-1 CLADE A CONSENSUS SEQUENCES, ANTIGENS, AND TRANSGENES
摘要 The present invention relates to consensus nucleotide and protein sequences for HIV-1 Clade A antigens, and to nucleotide and protein sequences for Clade A antigens from circulating HIV-1 field isolates wherein the antigen sequences are closely related to the these consensus sequences. Advantageously, the present invention relates to HIV-1 Clade A transgenes that are derived from such sequences, and that encode either HIV-1 Clade A Gag, Pol (RT and Int), and Nef (collectively“GRIN”), HIV-1 Clade A Gag, RT, and Nef (collectively“GRN”), or HIV-1 Clade A Env. The invention also relates to vectors containing such transgenes, including adenovirus vectors containing such transgenes. The invention also relates to immunogenic compositions comprising the HIV-1 Clade A antigens, nucleotide sequences, vectors, or transgenes of the invention, and to methods of generating an immune response against HIV in a subject by administering an effective amount of such immunogenic compositions.
申请公布号 US2012219577(A1) 申请公布日期 2012.08.30
申请号 US201213398897 申请日期 2012.02.17
申请人 GUPTA KALPANA;JACKSON NICHOLAS 发明人 GUPTA KALPANA;JACKSON NICHOLAS
分类号 A61K39/21;A61K31/711;A61P37/02;C07H21/04;C12P21/00 主分类号 A61K39/21
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