发明名称 METHOD FOR PRODUCING PEPTIDE
摘要 <p>METHOD FOR PRODUCING PEPTIDEThe mresent invention provides a method for producing a peptide, characterized in that it comprises converting an -SR group of a peptide comprising an amino acid residue having the -SH group to an -OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an -SH group in a peptide to react with a methylating agent to convert the -SH group to angroup; (b) allowing the -SMe group obtained in the step(a) to react with a cyaning agent to prodmce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an -0H group under more basic conditions than the conditions in the step: (b) .No figure</p>
申请公布号 SG183068(A1) 申请公布日期 2012.08.30
申请号 SG20120054441 申请日期 2008.07.30
申请人 OTSUKA CHEMICAL CO., LTD. 发明人 KAJIHARA, YASUHIRO;SAKAMOTO, IZUMI;NAMBU, YURI;FUKAE, KAZUHIRO;ASAI, HIROAKI
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