| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an external preparation which can retain an agent, for a long time, at an infected site and a ringworm fungus living region in the vicinity thereof upon treatment of nail ringworm. <P>SOLUTION: The external preparation for treating ringworm is composed of a water-containing gel base material dispersedly holding endoplasmic reticulums obtained by carrying constituents effective for ringworm fungus and further blended with an agent promoting skin permeation. The particle diameter of the endoplasmic reticulums is controlled so as to pass through the pores of a nail or a skin and the pores of a stratum corneum and so as not to pass through the gaps of capillary endothelial cells, further, the group of the endoplasmic reticulums is made easy to be introduced into a nail underfloor region and/or a subdermal region with a skin permeation promoter, and further, the active constituents can be retained in the region at high concentration. <P>COPYRIGHT: (C)2012,JPO&INPIT |
