| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide methods and compositions for treatment of IgE-mediated allergic disorders comprising an immunogenic amount of one or more antigenic peptides derived from CH3 domain or junction of CH3/CH4 domain of an IgE molecule, and to provide methods for the evaluation of IgE-mediated allergies in dogs. <P>SOLUTION: The invention relates to compositions comprising at least one antigenic peptide derived from the CH3 domain or CH3-CH4 domain junction of an IgE molecule coupled to a heterologous carrier protein. The compositions induce anti-IgE antibodies, which bind to soluble IgE in serum and other bodily fluids, but do not cross-link with receptor-bound IgE. The invention relates to methods for administering compositions to animals, preferably mammals and most preferably humans, for the treatment or prevention of IgE-mediated allergic disorders and methods for evaluating vaccines and other therapies for the treating IgE-mediated allergic disorders. <P>COPYRIGHT: (C)2012,JPO&INPIT |
