发明名称 |
Pyrrolopyrimidine compounds as inhibitors of CDK4/6 |
摘要 |
<p>The invention is directed to novel pyrrolopyrimidine compounds of formula (I) wherein R, R, R, R- R, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.</p> |
申请公布号 |
AU2011217286(A1) |
申请公布日期 |
2012.08.30 |
申请号 |
AU20110217286 |
申请日期 |
2011.02.17 |
申请人 |
NOVARTIS AG |
发明人 |
BRAIN, CHRISTOPHER THOMAS;CHO, YOUNG SHIN;GIRALDES, JOHN WILLIAM;LAGU, BHARAT;LEVELL, JULIAN;LUZZIO, MICHAEL;PEREZ, LAWRENCE BLAS;WANG, YAPING;YANG, FAN |
分类号 |
C07D487/04;A61K31/519;A61P35/00;C07B59/00;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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