| 摘要 |
The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided. |
| 申请人 |
CRAWFORD CLAIRE FRANCES;GARCIA SANDRINE;GRAHAM JONATHAN PAUL;HARLING SANDRA JANE;HENLEY NICHOLAS PAUL;HERMITAGE STEPHEN ANDREW;HUTCHINSON JOHN HOWARD;KEEL TREVOR RAYMOND;KENNEDY ANDREW;MASON ANDREW MCMURTRIE;SCOTT MARK SIMON;SMITH NEIL MICHAEL;STOCK NICHOLAS SIMON;TATENO YUICHI;TROUW LEONTINE SASKIA;TURNER PETER GRAHAM;WALLIS CHRISTOPHER JOHN;WILLACY ROBERT DAVID |
发明人 |
CRAWFORD CLAIRE FRANCES;GARCIA SANDRINE;GRAHAM JONATHAN PAUL;HARLING SANDRA JANE;HENLEY NICHOLAS PAUL;HERMITAGE STEPHEN ANDREW;HUTCHINSON JOHN HOWARD;KEEL TREVOR RAYMOND;KENNEDY ANDREW;MASON ANDREW MCMURTRIE;SCOTT MARK SIMON;SMITH NEIL MICHAEL;STOCK NICHOLAS SIMON;TATENO YUICHI;TROUW LEONTINE SASKIA;TURNER PETER GRAHAM;WALLIS CHRISTOPHER JOHN;WILLACY ROBERT DAVID |
