Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding peptides and methods of use thereof

摘要

The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express PNAG such as but not limited to and . Some antibodies of the invention enhance opsonophagocytic killing and protection against bacteria that express PNAG such as but not limited to and . Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.